The Gunners are looking for an immediate return to winning ways following their shock 1-0 defeat to West Ham at the Emirates last weekend.
Having failed to cut Liverpool's lead down to five points, the north London outfit now trail Arne Slot's men by 11 points following the Reds' 2-0 triumph at Manchester City.
Many Gooners now feel as though their title tilt is all-but over - and a defeat to Forest could leave them in a fight for a top four spot.
Just six currently separates Arsenal in second and Forest in third, and with Manchester United and Chelsea on the horizon for Arteta's side, they know they can't afford a second successive loss.
But they know they will be in store for a tough night with the club without their four key forwards in Bukayo Saka, Kai Havertz, Gabriel Jesus and Gabriel Jesus.
Goals from Jesus and Saka at the City Ground last term helped Arsenal claim all three points, while the latter also scored in the 3-0 win over Forest in November.
While the club are undoubtedly light up top, they have been boosted by the return of versatile defender Ben White, who is finally back to full fitness following his knee surgery.
He made his first appearance for the club since the 1-1 draw at Stamford Bridge on November 10 in the defeat to the Hammers.